Wilprafen Solutab pills dispersed 1000mg N10
Condition: New product
971 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Josamycin
Release form
Pills
Composition
1 tablet contains: josamycin propionate 1067.66 mg, which corresponds to the content of josamycin 1000 mg. Excipients: microcrystalline cellulose - 564.53 mg, hyprolosis - 199.82 mg, sodium dokuzat - 10.02 mg, aspartame - 10.09 mg, colloidal silicon dioxide - 2.91 mg, strawberry flavor - 50.05 mg, magnesium stearate - 34.92 mg.
Pharmacological effect
Antibacterial drug from the group of macrolides. The mechanism of action is associated with impaired protein synthesis in the microbial cell due to reversible binding to the 50S-subunit of the ribosome. In therapeutic concentrations, as a rule, has a bacteriostatic effect, slowing the growth and reproduction of bacteria. When creating a high concentration of inflammation in the outbreak, a bactericidal effect is possible. Josamycin is active against gram-positive bacteria: Staphylococcus spp. (including methicillin-sensitive strains of Staphylococcus aureus), Streptococcus spp. (including Streptococcus pyogenes and Streptococcus pneumoniae), Corynebacterium diphtheriae, Listeria monocytogenes, Propionibacterium acnes, Bacillus anthracis, Clostridium spp. Peptococcus spp., Peptostreptococcus spp .; Gram-negative bacteria: Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Bordetella spp., Brucella spp., Legionella spp., Haemophilus ducreyi, Haemophilus influenzae, Helicobacter pyli, CampyloTychrothers, I use your own home remedies, for example, hemophilus influenzae as well as for Chlamydia spp. (including Chlamydia trachomatis), Chlamydophila spp. (including Chlamydophila pneumoniae / previously called Chlamydia pneumoniae /), Mycoplasma spp., incl. Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma spp., Treponema pallidum, Borrelia burgdorferi. As a rule, it is not active against enterobacteria, therefore it has little effect on the gastrointestinal microflora. In some cases, retains activity with resistance to erythromycin and other 14 - and 15-membered macrolides (streptococci, staphylococci). Resistance to josamycin is less common than to 14- and 15-membered macrolides.
Pharmacokinetics
Absorption: After oral administration, josamycin is rapidly absorbed from the gastrointestinal tract. Food intake does not affect bioavailability. Сmax is reached 1 hour after administration. When taken in a dose of 1 g C max in plasma is 2-3 μg / ml. Distribution: Plasma protein binding is about 15%. Josamycin is well distributed in organs and tissues (with the exception of the brain), creating concentrations higher than plasma and remaining at a therapeutic level for a long time. Josamycin creates particularly high concentrations in the lungs, tonsils, saliva, sweat and tears. Concentration in sputum exceeds plasma concentration by 8-9 times. It passes the placental barrier, is secreted into breast milk. Metabolism: Josamycin is metabolized in the liver to less active metabolites.Excretion: Excreted mainly in the bile, excretion in the urine does not exceed 10%. T1 / 2 - 1-2 hours. Pharmacokinetics in special clinical situations. In patients with impaired liver function, an increase in T1 / 2 is possible.
Indications
Infectious and inflammatory diseases caused by susceptible microorganisms: Infections of the upper respiratory tract and ENT organs (pharyngitis, tonsillitis, paratonsillitis, laryngitis, otitis media, sinusitis). Diphtheria (in addition to treatment with diphtheria antitoxin). Scarlet fever (with penicillin hypersensitivity). Lower respiratory tract infections (acute bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia, including those caused by atypical pathogens). Whooping cough. Psittacosis. Infections of the oral cavity (gingivitis, pericoronitis, periodontitis, alveolitis, alveolar abscess). Eye infections (blepharitis, dacryocystitis). Infections of skin and soft tissues (folliculitis, furuncle, furunculosis, abscess, acne, lymphangitis, lymphadenitis, phlegmon, felon, wound / including postoperative / and burn infections). Anthrax. Erysipelas (with hypersensitivity to penicillin). Infections of the urinary tract and genital organs (urethritis, cervicitis, epididymitis, prostatitis caused by chlamydia and / or mycoplasmas). Venereal lymphogranuloma. Gonorrhea, syphilis (in case of hypersensitivity to penicillin). Diseases of the gastrointestinal tract associated with Helicobacter pylori (including gastric ulcer and duodenal ulcer, chronic gastritis).
Contraindications
Severe abnormal liver function. Children weighing less than 10 kg. Hypersensitivity to the drug. Hypersensitivity to macrolide antibiotics.
Precautionary measures
On the part of the digestive system: often - discomfort in the stomach, nausea; infrequently - abdominal discomfort, vomiting, diarrhea; rarely - stomatitis, constipation, loss of appetite; very rarely - pseudomembranous colitis. Allergic reactions: rarely - urticaria, angioedema and anaphylactoid reaction; very rarely - bullous dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome). On the part of the liver and biliary tract: very rarely - hepatic dysfunction, jaundice. On the part of the senses: in rare cases, dose-dependent transient hearing impairment has been reported.
Use during pregnancy and lactation
Use during pregnancy and during breastfeeding after a medical evaluation of the benefit / risk is permitted. The WHO European Office recommends josamycin as the drug of choice in the treatment of chlamydial infection in pregnant women.
Dosage and administration
The recommended daily dose for adults and adolescents over the age of 14 years is 1-2 g in 2-3 doses. If necessary, the dose can be increased to 3 g / day. Children aged 1 year have an average body weight of 10 kg. The daily dose for children weighing at least 10 kg is prescribed on the basis of 40–50 mg / kg body weight daily, divided into 2–3 doses: 250–500 mg (1 / 4-1 / 2 tab., Dissolved in water) 2 times / day, children with a body weight of 20-40 kg are prescribed 500-1000 mg each (1 / 2-1 tab., Dissolved in water) 2 times / day, children weighing more than 40 kg - 1000 mg (1 tab.) 2 times / day. Typically, the duration of treatment is determined by the doctor and ranges from 5 to 21 days depending on the nature and severity of the infection. In accordance with WHO recommendations, the duration of treatment of streptococcal tonsillitis should be at least 10 days. In the schemes of antihelicobacter therapy, josamycin is prescribed in a dose of 1 g 2 times / day for 7-14 days in combination with other drugs in their standard doses: - famotidine 40 mg / day or ranitidine 150 mg 2 times / day + josamycin 1 g 2 times / day + metronidazole 500 mg 2 times / day; - omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or rabeprazole 20 mg) 2 times / day + amoxicillin 1 g 2 times / day + josamycin 1 g 2 times / day; - omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or Rabeprazole 20 mg) 2 times / day + amoxicillin 1 g 2 times / day + josamycin 1 g 2 times / day + bismuth tri-potassium dicyrate 240 mg 2 times / day; - famotidine 40 mg / day + furazolidone 100 mg 2 times / day + josamycin 1 g 2 times / day + bismuth tri-potassium dicitrate 240 mg 2 times / day). In the presence of atrophy of the gastric mucosa with achlorhydria, confirmed by pH-metry: amoxicillin 1 g 2 times / day + josamycin 1 g 2 times / day + bismuth trikalitic citrate 240 mg 2 times / day. For common and spherical acne, it is recommended to prescribe josamycin in a dose of 500 mg 2 times / day for the first 2-4 weeks, then - 500 mg of josamycin 1 time / day as a supportive treatment for 8 weeks. Dispersible pills Wilprafen Solutab can be taken in various ways: the tablet can be swallowed whole, washed down with water or previously, before taking, dissolved in water. Tablets should be dissolved in at least 20 ml of water.Stir the resulting suspension well before taking it.
Side effects
On the part of the digestive system often - discomfort in the stomach, nausea. infrequently - abdominal discomfort, vomiting, diarrhea. rarely - stomatitis, constipation, loss of appetite. very rarely - pseudomembranous colitis. Allergic reactions rarely - urticaria, angioedema and anaphylactoid reaction. very rarely - bullous dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome). On the side of the liver and biliary tract it is very rare - hepatic dysfunction, jaundice. On the side of the sense organs, in rare cases, dose-dependent transient hearing impairment has been reported. Other very seldom - purpura.
Overdose
So far, there are no data on the specific symptoms of an overdose of the drug Wilprafen Solutab. In the case of overdose, the occurrence and intensification of side effects, especially on the part of the digestive system, should be assumed.
Interaction with other drugs
Since In vitro bacteriostatic antibiotics are capable of reducing the antimicrobial effect of bactericidal antibiotics, their joint use should be avoided. Josamycin should not be administered together with lincosamides, since perhaps a mutual decrease in their effectiveness. Some representatives of the macrolide group slow down the elimination of xanthines (theophylline), which can lead to signs of intoxication. Clinical and experimental studies indicate that josamycin has less effect on theophylline elimination than other macrolides. When co-administered with josamycin and antihistamine preparations containing terfenadine or astemizole, the risk of developing life-threatening arrhythmias may increase. There are separate reports of increased vasoconstriction after co-administration of ergot alkaloids and macrolide antibiotics, incl. Single observation on the background of taking josamycin. Co-administration of josamycin and cyclosporine may cause an increase in plasma levels of cyclosporine and increase the risk of nephrotoxicity. Plasma cyclosporine concentration should be regularly monitored. With the joint appointment of josamycin and digoxin may increase the level of the latter in the blood plasma.
special instructions
In the case of persistent severe diarrhea, the possibility of life-threatening pseudomembranous colitis in the presence of josamycin should be kept in mind. In patients with renal insufficiency, treatment should be carried out taking into account the results of relevant laboratory tests (definition of clearance of endogenous creatinine). Consideration should be given to the possibility of cross-resistance to various macrolide antibiotics (microorganisms that are resistant to treatment with antibiotics related by chemical structure may also be resistant to josamycin). Influence on the ability to drive motor vehicles and control mechanisms: The influence of the drug on the ability to drive vehicles and work with mechanisms was not observed.